Killing Drug-Resistant Bacteria

Killing Drug-Resistant Bacteria 

Using generative AI, researchers design compounds that can kill drug-resistant bacteria

The team used two different AI approaches to design novel antibiotics, including one that showed promise against MRSA.

eventually narrowing the pool down to about 90 compounds.
They were able to synthesize and test 22 of these molecules, and six of them showed strong antibacterial activity against multi-drug-resistant S. aureus grown in a lab dish. They also found that the top candidate, named DN1, was able to clear a methicillin-resistant S. aureus (MRSA) skin infection in a mouse model. These molecules also appear to interfere with bacterial cell membranes, but with broader effects not limited to interaction with one specific protein.
Phare Bio, a nonprofit that is also part of the Antibiotics-AI Project, is now working on further modifying NG1 and DN1 to make them suitable for additional testing.
“In a collaboration with Phare Bio, we are exploring analogs, as well as working on advancing the best candidates preclinically, through medicinal chemistry work,” Collins says. “We are also excited about applying the platforms that Aarti and the team have developed toward other bacterial pathogens of interest, notably Mycobacterium tuberculosis and Pseudomonas aeruginosa.”
The research was funded, in part, by the U.S. Defense Threat Reduction Agency, the National Institutes of Health, the Audacious Project, Flu Lab, the Sea Grape Foundation, Rosamund Zander and Hansjorg Wyss for the Wyss Foundation, and an anonymous donor.

REFERENCE 

https://news.mit.edu/2025/using-generative-ai-researchers-design-compounds-kill-drug-resistant-bacteria-0814

The five phases in acceptance of death, as described by Elisabeth Kübler-Ross, are denial, anger, bargaining, depression, and acceptance. These stages are not always experienced in a linear order, and individuals may fluctuate between them or skip some altogether. 

Here's a more detailed look at each stage:

• 1. Denial:
This is the initial stage where the individual refuses to accept the reality of the situation, often acting as if it is not happening or as if it is not real. 

• 2. Anger:
As the reality of the situation sets in, anger may arise. This anger can be directed at loved ones, medical professionals, or even God. 

• 3. Bargaining:
In this stage, the individual may try to negotiate with a higher power or make deals to postpone or prevent the inevitable. They might promise to change their behavior or make amends if their situation improves. 

• 4. Depression:
As bargaining proves unsuccessful, the individual may experience sadness, withdrawal, and a sense of hopelessness. 

• 5. Acceptance:
This final stage involves acknowledging the reality of the situation and finding a way to live with it. It's not necessarily a happy or cheerful state, but rather a peaceful resignation and an ability to move forward. 
While these stages provide a framework for understanding the grieving process, it's important to remember that grief is a highly personal experience. Not everyone goes through all the stages, and the order in which they are experienced can vary greatly according to HelpGuide.org. 

Laundry Folder + Robot 

https://interestingengineering.com/innovation/humanoid-robot-uses-helix-ai-to-fold-towels

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